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- W2392279551 abstract "OBJECTIVE To evaluate whether T-type CCBs are equivalent with or superior to ACEIs /ARBs on renal outcomes in hupertensive patients with chronic kidney disease. METHODS Cochrane Library,Pubmed,EMbase and CNKI were searched for relevant randomized controlled trials( RCTs) from inception to May 2012. The meta-analysis was performed by Revman 5. 1 software.RESULTS Five RCTs( 563 subjects) were included in the present study. T-type CCBs performed a pooled improvement in creatinine clearance and glomerular filtration rate similar to ACEIs / ARBs but were inferior to ACEIs / ARBs on reducing proteinuria excretion( three RCTs,389 subjects,WMD 0. 26 g·d- 1,95% CI 0. 10 to 0. 43),although T-type CCBs and ACEIs/ARBs showed stable anti-hypertensive effect. CONCLUSION Our findings suggest that despite T-type CCBs do offer salutary effects on kidney outcomes and hypertension can be applied to treat hypertensive patients with chronic kidney disease,ACEIs / ARBs might be better choice for pressure control in this target population especially when proteinuria is the main issue of renal dysfunction." @default.
- W2392279551 created "2016-06-24" @default.
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- W2392279551 date "2013-01-01" @default.
- W2392279551 modified "2023-09-23" @default.
- W2392279551 title "A System Review: The Effects of T-type CCB or ACEI /ARB for Hypertensive Patients with Chronic Kidney Disease" @default.
- W2392279551 hasPublicationYear "2013" @default.
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