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- W2392281749 abstract "Objective:To investigate the effects of angiotensin converting enzyme inhibitor(ACEI) benazepril and all-trans retinoic acid(ATRA) on early diabetic nephropathy and blood biochemical indicators.Methods:Adult male Wistar rats were divided into normal control(distilled water intragastric administration),DN (distilled water intragastric administration),benazepril (ACEI) groups (benazepril intragastric administration),ATRA groups(ATRA intragastric administration).Physiological and biochemical changes,histological changes of kidney tissue were observed 4 weeks later.Results:After 4 weeks,the body weight of DN groups,ACEI groups and the ATRA groups increased slowly,blood glucose level was significantly higher in DN、ACEI groups and the ATRA groups than that of normal control group (P0.01).Kidney weight,kidney hypertrophy index,urinary albumin (UAlb) /urine creatimine (Ucr) in DN group were obviously higher than those of normal control group; but the above indexes in ACEI and ATRA groups were all significantly decreased compared with those of DN group.Kidney pathology showed that renal glomeruli size was larger in group DN than their normal controls,and also the mesangial matrix.Above mentioned changes of ACEI and ATRA groups were lighter than DN Group,mesangial matrix lightly increased.But there were no significant differences between ACEI group and ATRA group.Conclusion:There were effects of benazepril and ATRA on early diabetic nephropathy treatment.And it caould provide clues of prevention and treatment of early DN.but no significant difference between them." @default.
- W2392281749 created "2016-06-24" @default.
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- W2392281749 date "2010-01-01" @default.
- W2392281749 modified "2023-09-23" @default.
- W2392281749 title "Effects of Benazepril and ATRA in Early Diabetic Nephropathy Rats" @default.
- W2392281749 hasPublicationYear "2010" @default.
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