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- W2392284206 abstract "【Objective】To determine the change of the concentration of motilin(MOT) in plasma,5-hydroxytryptamine(5-HT) in plasma and nitric oxide(NO) in serum dynamically after recieving 1%(high) cholesterol diet.【Methods】45 healthy adult guinea pigs were included in the study and were randomly assigned to the following groups:Group A: fifteen animals received a trace(control group) for two weeks.Group B: fifteen animals recieved a 1%(high) cholesterol diet for two weeks.Group C:fifteen animals daily received a 1%(high) cholesterol diet for four weeks.Plasma concentration of MOT,5-HT and serum concentration of NO were measured.【Results】While recieving 1%(high) cholesterol diet for two weeks,the plasma level of MOT and 5-HT were significantly higher than that of the control group(P0.01) and the serum NO level was lower significantly than that of the control group(P0.01).While recieving 1%(high) cholesterol diet for four weeks,the plasma level of 5-HT and serum MOT increased significantly as compared with the control group(P0.01) and with group B(P0.05).While recieving 1%(high) cholesterol diet for four weeks,the serum NO level was lower significantly than that of the control group(P0.01) and that of group B(P0.05).【Conclusions】During the early stage of cholesterol gallstone formation the plasma level of MOT is increased and the plasma level of 5-HT is higher as compared with the control group,while the NO level in serum is lower than that of the control group." @default.
- W2392284206 created "2016-06-24" @default.
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- W2392284206 date "2008-01-01" @default.
- W2392284206 modified "2023-09-23" @default.
- W2392284206 title "Experimental study on the changes of gastrointrstinal hormones during early stage of cholesterol gallstone formation" @default.
- W2392284206 hasPublicationYear "2008" @default.
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