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- W2392291642 abstract "Objective To investigate the protective effects and mechanism of TG6 on myocardial ischemia/reperfusion injury.Methods the protective effects of TG6 on myocardial ischemia / reperfusion was investigated by setting up models of ischemia and reperfusion of rats induced by ligating the left coronary anterior descending artery in vivo,isolated rat hearts through an improved Langendorff device,and hypoxia / reoxygenation injury of neonatal rat cardiomyocytes,and the serum CK,LDH,T-SOD,MDA were taken as research markers.Results TG6 significantly reduced the myocardial infarct size,decreased the activity of CK and the content of MDA in serum,reduced the activity of LDH,and increased the activity of T-SOD in vivo;TG6 obviously increased the coronary blood flow after low rate perfusion and reperfusion,decreased the content of MDA and the leakage of CK,LDH in myocardial tissue,elevated the activity of T-SOD in vitro of isolated rat hearts;TG6 had no effects on cells in normal growth condition,raised the viability of cardiomyocytes significantly,and reduced the rate of CK leakage and the content of [Ca2 +]iobviously in Na2S2O4 treated cells in vitro of neonatal rat cardiomyocytes.Conclusion TG6 could effectively protect myocardial ischemia / reperfusion injury." @default.
- W2392291642 created "2016-06-24" @default.
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- W2392291642 date "2014-01-01" @default.
- W2392291642 modified "2023-09-23" @default.
- W2392291642 title "Effects and mechanism of TG6 on myocardial ischemia and reperfusion injury" @default.
- W2392291642 hasPublicationYear "2014" @default.
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