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- W2392301364 abstract "OBJECTIVE:To investigate the arrest effect of diallyl disulfide (DADS) in the cell cycle of human nasopharyngeal carcinoma SW480 cell line and its molecular mechanism. METHODS: The growth inhibition effect of different concentrations of DADS (50 μg/mL) on SW480 cell line was measured by MTT assay and cell counting. Apoptosis rate was analyzed by flow cytometry. CK19 mRNA level was detected by RT-PCR. The expression of CK19 was determined by Western blotting analysis. RESULTS: The MTT assay showed that DADS inhibited growth of SW480 cells significantly with dose dependent. There was a significant difference between the treated and controlled cases (P0.05). Cell counting results showed that average doubling time increased with the dose increase of DADS, compared with normal cultured SW480 cells (P0.05). Flow cytometry analysis revealed that SW480 cells treated with 50 μg/mL DADS increased the apoptosis rate. CK19 mRNA was decreased in SW480 treated with 50 μg/mL DADS using RT-PCR. CK19 was decreased significantly in SW480 treated with 50 μg/mL DADS by using Western blotting. The differences were more than two timesc. CONCLUSION: The anti-proliferation property of DADS in cultured human colon carcinoma SW480 cell line may relate to its ability of increasing the apoptosis rate through down-regulation of CK19." @default.
- W2392301364 created "2016-06-24" @default.
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- W2392301364 date "2009-01-01" @default.
- W2392301364 modified "2023-09-23" @default.
- W2392301364 title "Proliferation inhibition effects by DADS in SW480 cell line and identification of CK19 protein" @default.
- W2392301364 hasPublicationYear "2009" @default.
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