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- W2392327090 abstract "Objective To observe the effect of the antibody TSP-2 against a single epitope of mouse Toll-like receptor 2 extracellular domain(mTLR2ECD) on the expression of nuclear factor-kappa B(NF-κB) and cytokines in the intestinal tissue of septic mice.Method Male BALB/c mice were randomly divided into 4 groups,namely the sham-operated group,model group,TSP-2 treatment group and rabbit IgG treatment group.Sepsis was induced by cecal ligation and puncture(CLP),and at 6,12 or 24 h after the operation,the ileal tissues were harvested from the mice for HE staining.NF-κB expression was detected with immunohistochemistry.Tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) mRNA expressions were detected with qRT-PCR and their protein expressions by ELISA.Results The NF-κB expression in the intestinal tissue significantly increased in the model group as compared with that in the sham-operated group,and decreased after TSP-2 treatment.The model group also showed significantly increased expression levels of TNF-α and IL-6 mRNA and protein in the intestinal tissue(P0.05),which were lowered by TSP-2(P0.05) but not by rabbit IgG treatment(P0.05).Conclusion The TSP-2 antibody can protect the intestine and delay the development of sepsis by inhibiting NF-κB activation and down-regulating TNF-α and IL-6 expressions in mice." @default.
- W2392327090 created "2016-06-24" @default.
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- W2392327090 date "2011-02-01" @default.
- W2392327090 modified "2023-10-05" @default.
- W2392327090 title "[Effect of TSP-2 antibody against a single epitope of mouse Toll-like receptor 2 extracellular domain on nuclear factor-kappa B and cytokine expression in the intestine of septic mice]." @default.
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