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- W2392330462 abstract "Objective To study apoptosis of lung carcinoma SPCA-1 cell line induced by SeO 2. Methods: Trypan blue dying and Methyl thiazolyl tetrazolium(MTT) was used to observe the growth inhibition rates of SPCA-1 cells by various concentration of SeO 2 at different time ponts. Apoptosis percentage and cell cycle phase distribution of SPCA-1 were measured by flow cytometry (FCM) assays. Apoptotic phenotype of SPCA-1 was observed by HE dying and electric microscope . Results: SeO 2 could inhibit the growth of SPCA-1 cells effectively and depended on the action time and concentration of the medicine. SPCA-1 cell apoptotic percentage induced by SeO 2 was enhanced in concentration-dependent pattern. S phase cell of SPCA-1 were arrested in lower concentration of SeO 2, while higher concentration induced apoptosis selectively. SPCA-1 cells treated by SeO 2 showed morphological characteristic of apoptotic cells. Conclusion: SeO 2 can inhibit the proliferation of lung carcinoma SPCA-1 cells by inducing S phase cells apoptosis, and it is time-dependent and concentration-dependent and cell cycle specific." @default.
- W2392330462 created "2016-06-24" @default.
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- W2392330462 date "2003-01-01" @default.
- W2392330462 modified "2023-09-24" @default.
- W2392330462 title "Induction of apoptosis in human lung carcinoma SPCA-1 cell line by selenium dioxide(SeO_2)" @default.
- W2392330462 hasPublicationYear "2003" @default.
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