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- W2392341793 abstract "Objective To investigate the effect of atorvastatin on nonalcoholic steatohepatitis(NASH) induced by hig-fat diet in rats.Methods Twenty-three SD rats were randomly divided into three groups of NC(normal controls,8 rats),HF(treated with high-fat diet,7 rats) and HF+AT(treated with high-fat diet plus atorvastatin,8 rats).The changes of related criteria in serum and the liver of rats were observed.The mRNA expressions of nuclear factor kappa B(NF-κB),tumor necrosis factor-α(TNF-α) and peroxisome proliferators-activated receptorγ(PPARγ) were detected by RT-PCR.Results Compared with group HF,serum criteria were significantly improved,adipose degeneration and inflammation in the liver were decreased,the mRNA expressions of NF-κB and TNF-α were decreased,whereas the expression of PPARγ mRNA was increased in group HE+AT(P0.05 or P0.01).Conclusion Atorvastatin can attenuate NASH induced by high-fat diet in rats." @default.
- W2392341793 created "2016-06-24" @default.
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- W2392341793 date "2011-01-01" @default.
- W2392341793 modified "2023-09-23" @default.
- W2392341793 title "Effect of atorvastatin on nonalcoholic steatohepatitis induced by high-fat diet in rats" @default.
- W2392341793 hasPublicationYear "2011" @default.
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