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- W2392342406 abstract "OBJECTIVE To investigate the effects of GLB 7 on inositol trisphosphate(IP 3)and diacylglycerol(DAG) in murine T cell and to provide a scientific evidence for its immunomodulatory mechanism.METHOD Cell culture,radio-immunological asssy, anion-exchange columns and thin-layer chromatography were used.RESULT GLB 7 increased the production of IP 3 and DAG in mice.The peak of IP 3 was approached at 30 s.Pertussis toxin(PTX) inhibited GLB 7 from increasing the production of IP 3.In the production of DAG,two peak were found,the first peak was rapid and transitory, and the second was delayed. GLB 7 didnt influence the production of IP 3 and DAG in active T cells.CONCLUSION The both paths of signal transduction of IP 3/Ca 2+ and DAG/PKC were involved in the immunomodulatory of GLB 7 to T cells." @default.
- W2392342406 created "2016-06-24" @default.
- W2392342406 creator A5053320254 @default.
- W2392342406 date "2001-01-01" @default.
- W2392342406 modified "2023-10-06" @default.
- W2392342406 title "Effects of ganoderma lucidum polysaccharides on inositol trisphosphate and diacylglycerol in murine T cells" @default.
- W2392342406 hasPublicationYear "2001" @default.
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