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- W2392357152 abstract "To detect the The levels of IFN-γand IL-12 and IL-12 gene expression and the activation of NF-AT in peripheral mononuclear cells (PBMC) in patients of uveitis and investigate their relationship on uveitis Methods The levels of IFN-γand IL-12 were detected by ELISA; the IL-12mRNA was detected by situ hybridization(ISH)respectively; the activity of NF-AT was detected by electrophoretic mobility shift assay(EMSA). Result: The levels of IFN-γ?IL-12 and IL-12 gene expression and the activation of NF-AT in PBMC from the patients of uveitis were significance higher than normal contrast and other patients of ophthalmopathy (P0.01).Conclusion: The abnormal expression of IL-12?IFN-γ and NF-AT, which is suggested that may contribute to the pathogenesis of uveitis .These results prompt that the imbalance of Th 1/Th 2 cell might exist in patients with uveitis. The significance higher of the regulation by NF-AT at transcription level may be associated with reinforcement transcription of IFN-γ in uveitis." @default.
- W2392357152 created "2016-06-24" @default.
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- W2392357152 date "2002-01-01" @default.
- W2392357152 modified "2023-09-23" @default.
- W2392357152 title "Determination of the Disease Correlative Cytokines Expressed by Peripheral Blood Mononuclear Cells from Patients of Uveitis" @default.
- W2392357152 hasPublicationYear "2002" @default.
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