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- W2392361208 abstract "AIM To study the anti inflammatory effects of benzoisoselenothiazolidonesulfonamide derivatives, compounds A and B. METHODS Boyden chamber was used to examine the chemotaxis of polymorphonuclear leukocyte. Myeloperoxidase activity was assayed by spectrophotometry. Dying method was used to study degranulation of mastocytes. RESULTS Compounds A and B were shown to inhibit the chemotaxis of polymorphonuclear leukocyte stimulated by fMLPP with IC 50 of 1 3×10 -8 mol·L -1 and 1 19×10 -10 mol·L -1 , respectively. In the model of mouse ear edema induced by croton oil, the rates of inhibition of myeloperoxidase activity after compounds A and B applied to the dorsal surface of mouse ear were 49% for compound A at the dose of 1 mg/mouse, 37% and 51% for compound B at the doses of 0 1 mg/mouse and 1 mg/mouse, respectively. Compounds A and B(10 -7 ～10 -5 mol·L -1 ) showed dose dependent inhibitory activity relationship with respect to the degranulation of mastocytes response to compound 48/80. CONCLUSION Benzoisoselenothiazolidonesulfonamide derivatives compound A and compound B showed obvious anti inflammatory effects." @default.
- W2392361208 created "2016-06-24" @default.
- W2392361208 creator A5053347727 @default.
- W2392361208 date "2000-01-01" @default.
- W2392361208 modified "2023-09-24" @default.
- W2392361208 title "THE ANTI-INFLAMMATORY ACTIONS OF BENZOISOSELENOTHIAZOLIDONESULFONAMIDE DERIVATIVES" @default.
- W2392361208 hasPublicationYear "2000" @default.
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