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- W2392373901 abstract "Objective To investigate the expression of IGF-ⅠR and the relationship between clinical stage,pathological grade,lymph node metastasis etc in laryngeal squamous cell carcinoma(LSCC).Methods The expression of IGF-ⅠR protein were detected by immunohistochemistry technique in 60 cases of LSCC,25 cases of adjacent nontumorous laryngeal epithelium,10 cases of normal laryngeal epithelium.Results The positive rate of IGF-ⅠR expression in LSCC was significant higher than that in the normal laryngeal epithelium and adjacent nontumorous laryngeal epithelium(P0.05).IGF-ⅠR positive expression was stronger in stageⅢ～Ⅳof LSCC,cervical lymph node metastasis cases and well differentiation of LSCC than that in stageⅠ～Ⅱ,non-lymph node metastasis cases and poor/mediate differentiation respectively(P0.05).Conclusion There was overexpression of IGF-VR in the laryngeal carcinoma,which may play an important role in the carcinogenesis and development of LSCC.Examination of IGF-ⅠR expression has a great significance in estimating prognosis of patients with LSCC." @default.
- W2392373901 created "2016-06-24" @default.
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- W2392373901 date "2009-01-01" @default.
- W2392373901 modified "2023-09-28" @default.
- W2392373901 title "Expression and Significance of IGF-IR in Laryngeal Squamous Cell Carcinoma" @default.
- W2392373901 hasPublicationYear "2009" @default.
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