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- W2392381036 abstract "Objective To evaluate the efficacy and safety of S-1 combined with irinotecan in the treatment of patients with advanced colorectal cancer.Methods 64 patients with advanced colorectal cancer were randomly divided into two groups.The treatment group was administrated with S-1 plus irinotecan(irinotecan 180 mg/m2 infused intravenously for 2 h day 1;S-1 taken orally 80 mg/m2 day 1 to 14,repeated 21 days).The control group was administrated with oxaliplatin、CF and 5-Fu(oxaliplatin 85 mg/m2 infused intravenously for 3 h day 1,CF 200 mg/m2 and 5-Fu 400 mg/m2 infused intravenously day 1 to 5,repeated 21 days)。The efficacy and toxicities were reviewed after at least 4 cycles of chemotherapy.Results The effective rates were 56.25% and 31.25% in the treatment group and control group respectively.Treatment group was better than control group(P 0.05).The main toxicities included bone marrow suppression,nausea and vomiting,diarrhea,stomatitis.Conclusion S-1 combined Irinotecan in the treatment of advanced colorectal cancer is effective and has mild side effects.It helps the patients improve their survival rate and quality of life;it may be an effective chemotherapy." @default.
- W2392381036 created "2016-06-24" @default.
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- W2392381036 date "2012-01-01" @default.
- W2392381036 modified "2023-09-28" @default.
- W2392381036 title "Combination therapy with S-1 and irinotecan for patients with advanced colorectal cancer" @default.
- W2392381036 hasPublicationYear "2012" @default.
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