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- W2392394162 abstract "Objective To explore the expression of TGF-β_1 mRNA and protein in patients with hepatocellular carcinoma.Methods The expression of TGF-β_1?TβRⅡ protein in 36 cases of HCC and surrounding HCC tissue was separately detected using immunohistochemistry technique.The expression of TGF-β_1mRNA in 26 cases of HCC and surrounding HCC tissue was separately detected using the method of in situ hybridization.The relationship between TGF-β_1 mRNA and TGF-β_1 protein,TGF-β_1 mRNA and TβRⅡ protein was observed.Results The expression of TGF-β_1mRNA and TGF-β_1 protein in HCC tissue was higher than that in surrounding HCC tissue( P 0.01).But TβRⅡ protein was in opposite way( P 0.01).There was significant positive relativity between TGF-β_1 protein and TGF-β_1 mRNA,but the expression of TβRⅡ protein was negatively correlated with that of TGF-β_1 mRNA in HCC tissue.Conclusions Variation on TGF-β_1 gene may be associated with occurrence of HCC.The decline of inhibition of TGF-β_1 was due to the decline of expression of TβRⅡ protein.These results can provide the theoretical basis of the pathogenesis and gene therapy of HCC." @default.
- W2392394162 created "2016-06-24" @default.
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- W2392394162 date "2003-01-01" @default.
- W2392394162 modified "2023-09-24" @default.
- W2392394162 title "Studies on expression of TGF-β_1 mRNA and protein in patients with hepatocellular carcinoma" @default.
- W2392394162 hasPublicationYear "2003" @default.
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