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- W2392425008 abstract "Objective: To investigate the effect of kidney investigation on mRNA expression of TGF-β1 of osteoblastic cell. Methods: Osteoblatic cells of calvaria which were isolated andcultured from newborn fetal Sprague - Daw - ley rats had migu tablet liquor of differentcon-centration and recombinated basic fibroblastic growth factor (rbFGF) added. 24 hours later, insitu hybridization of os-teoblatic cells were analyzed by probe which was made by our lab. Themean optical density value of positive particles represented mRNA expression of TGF-β1. Results: MRNA expression of TGF-β1 in osteoblasts of experiental group was significantlyhigher than that of negative control group as the concentration of migu tablet liquor rised up. However, The optical density value of TGF-β1 in experimental groups which contained migutablet liquor at concentration of 5000 1μ g ml-1 and 1000 μ g ml-1 respectively had nosignificant difference with that in positive group(p 0.05) . Conclusion: Mign tablet couldstimulate the secretion and synthesis of TGF-β1 in osteoblats then promoted bone formation andinhab-ited bone resorption. This may be one of the mechanisms which kidney invigorationprevented and treated osteoporosis." @default.
- W2392425008 created "2016-06-24" @default.
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- W2392425008 date "2005-01-01" @default.
- W2392425008 modified "2023-09-23" @default.
- W2392425008 title "Effects of Kidney Invigoration on mRNA Expression of TGF-β1 of Osteoblastic Cell" @default.
- W2392425008 hasPublicationYear "2005" @default.
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