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- W2392431034 abstract "【Objective】 To explore the variation of P16-RB-E2F1(retinoblastoma,RB) signal pathway in lung fibroblasts of neonatal rats treated with hyperoxia.【Methods】 In 12 hours after birth,full-term newborn rats were continuously exposed to oxygen(0.85) or room air.Pups were randomly selected to be sacrificed on postnatal 3 d,7 d,14 d and 21 d,lungs were immediately resected under sterile condition and primary cell culture was done.The protein expressions of p16,RB,E2F1 in LF were detected by immunohistochemistry and Western-blot;the mRNA expressions of them in LF were detected by Real-Time PCR.RB proteins phosphorylated(p-RB) at serine 795 in LF were detected by immunohistochemistry.【Results】 Exposure neonatal rats in hyperoxia for 3 days did not change the expression of p16 and E2F1 in lung fibroblast.(P 0.05).However,the expression of P16 in hyperoxia groups was significant down-regulated but the expression of p-RB and E2F1 was significant up-regulated on 7 day,14 day and 21 day compared with that in air-exposed groups(P 0.05 on 7 day,P 0.01 on 14 day and 21 day).No notable difference was observed in the protein and mRNA expression of RB between hyperoxia groups and air-exposed groups.【Conclusion】 Exposure of neonatal rats in hyperoxia can down-regulate expression of p16 and up-regulate E2F1 expression,change the phosphorylation of RB protein,ultimately lead the pulmonary interstitial fibrosis." @default.
- W2392431034 created "2016-06-24" @default.
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- W2392431034 date "2011-01-01" @default.
- W2392431034 modified "2023-09-26" @default.
- W2392431034 title "Variation of P16-RB-E_2F_1 signal pathway in lung fibroblasts of neonatal rats treated with hyperoxia" @default.
- W2392431034 hasPublicationYear "2011" @default.
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