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- W2392434905 abstract "Objective To study preliminarily apoptosis of alveolar macrophages (AM) and tumor necrosis factor,as well as receptor (TNF-α/TNFR) signaling pathway of apoptosis of AM in the patients with pneumoconiosis,in order to provide some basis for prevention and treatment of pneumoconiosis.Methods 30 pneumoconiosis patients were chosen as subjects.AM obtained from the massive whole lung lavage fluid were purified and divided into 5 groups:untreated group,SOD group,TNF-α/TNFR group,anti-TNF-α group and Caspase-8 inhibitor Group.Cultured for 24 h,AM were harvested,and the apoptotic character was observed under light microscope,transmission electron microscope and fluorescence confocal microscope.SAS 8.2 software was used to analyze the difference between or among groups.Results Apoptosis AM showed typical morphological changes under the microscopes.There were no significant differences of apoptotic indexes among different ages,length of service,property of dust,beginning age exposed to dust.The apoptosis indexes in SOD group,anti TNF-α group,Caspase-8 inhibitor group of AM were lower than that of the untreated group.Conclusion Some apoptotic AM were found in pneumoconiosis patients,showing apoptotic characters of morphological changes.No significant differences among stages of pneumoconiosis were observed.SOD enzyme,anti-TNF-α antibody,Caspase-8 inhibitors might block signal transduction and inhibite the occurrence of apoptosis of AM." @default.
- W2392434905 created "2016-06-24" @default.
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- W2392434905 date "2010-01-01" @default.
- W2392434905 modified "2023-09-24" @default.
- W2392434905 title "Apoptosis of alveolar macrophages in patients with pneumoconiosis and its death signal regulatory mechanisms" @default.
- W2392434905 hasPublicationYear "2010" @default.
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