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- W2392448897 abstract "Objective To evaluate the value of serum creatinine(Scr),creatinine clearance (Ccr),MDRD equation 7(MDRD 7),~(99)Tc~m-DTPA renal dynamic imaging(gGFR)and cystatin C in screening changed glomerular filtration function in type 2 diabetic patients.Methods The ~(99)Tc~m-Diethylene Triamine Pentaacetic Acid(~(99)Tc~m-DTPA)plasma clearance(rGFR)obtained with the dual plasma sampling method was used as a reference with which Scr,Ccr,MDRD 7,gGFR and Cystatin C were compared.Results Sixty of type 2 diabetic patients were selected,including 35 male and 25 female.The average age was(62.4±11.7)years and the average diabetic history was(10.66±9.35)years.Scr,Ccr, MDRD 7,gGFR were all correlated significantly with rGFR.Correlation coefficients were 0.675 for Ccr, -0.588 for Cystatin C,-0.500 for Scr,O.428 for MDRD 7,0.367 for gGFR(P values all 0.001). The sensitivities of Ccr,MDRD 7 and Cystatin C were higher than that of Scr and gGFR;the specificity of Scr was 100%.The areas under the receiver operating characteristics curve(ROC)of Cystatin C and Ccr were significantly higher than that of Scr,7GFR and gGFR.ROC curves showed an optimum cut off of 1.18 mg/L for Cystatin C and the sensitivity and specificity were 80% and 57.5%.The optimum cut off for Ccr was 62 ml/min and the sensitivity and specificity were 90% and 67.9%.Conclusion Ccr and Cystatin C are better markers to reflect the changes of glomerular filtration rate in type 2 diabetic patients." @default.
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- W2392448897 date "2007-01-01" @default.
- W2392448897 modified "2023-09-23" @default.
- W2392448897 title "Evaluation of the glomerular filtration function in type 2 diabetic patients" @default.
- W2392448897 hasPublicationYear "2007" @default.
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