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• W2392470842 abstract "Objective To study the changes of coagulation function and its clinical significance in acute stroke with systemic inflammatory response syndrome (SIRS). Methods Two hundred and fifty two cases of acute stroke with SIRS were scored by Rankin standard for stroke within 24 hours after the admission. The laboratory indes related to coagulation function, such as prothrombin time (PT), thrombin time (TT), activated partial thromboplastic time (APTT) and D-dimer (DD) level and platelet counts (PLT) were determined. The relation between the items according to SIRS and the coagulation function disorder was observed. The coagulation function in the survival group and death group, critical group and non critical group, was compared. Results The percentage of critical cases and mortality rate in SIRS acute stroke increased with increasing items of criteria for diagnosis of SIRS, so did the PT, TT, APTT and DD level. The PT, TT, APTT and DD levels remarkably correlated with the items, while there was not a correlation between PLT counts and the items. There was no difference in the PT, TT, APTT level between the survival group and the death group (P0.05), while plasma levels of DD in death group was significantly higher than that in survival group (P0.01). The PT, TT, APTT and DD levels in critical group was higher than that in the non critical group (P0.01). Conclusions There was an activation of the coagulation system in the acute stroke with SIRS. The inflammation and coagulation were closely linked and interwoven. The more items of the diagnostic criteria for SIRS, the more severe the patients were; the more remarkable the coagulation disturbance was, the higher the mortality was. Early intervention should be taken in such cases in order to prevent the progression of SIRS, control the occurrence of DIC, and decrease the mortality rate of critical acute stroke." @default.
• W2392470842 created "2016-06-24" @default.
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• W2392470842 date "2006-01-01" @default.
• W2392470842 modified "2023-09-23" @default.
• W2392470842 title "Clinical Study on Coagulation Dysfunction in Acute Stroke with Systemic Inflammatory Response Syndrome" @default.
• W2392470842 hasPublicationYear "2006" @default.
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