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- W2392472402 abstract "Objective investigate the radiobiological characteristics of the nasopharyngeal carcinoma cell lines in different p53 function status. Methods pC53-SN3 plasmid containing wild-type p53 gene and the vector plasmid pCMV-Neo-Bam were transfected into the nasopharyngeal carcinoma cell lines CNE1 and CNE2, which displayed abnormal p53 function by Lipofectamine TM 2000 mediated transfection method. Western blot was used to evaluate the p53 function status of the cells. Clonogenic assay was performed to determine the survival fraction. The parameters D_0, Dq, and N for the single-hit multi-target model and the parameters α, β, α/β, and SF_2 for the linear-quadratic model were calculated. Methods Nasopharyngeal carcinoma cell lines possessed normal p53 function after having been transfected with wild-type p53 gene. The CNE1-pNeo and CNE1-wtp53 cells had the D_0 parameters of 1.17?Gy and 1.08?Gy, the Dq parameters of 2.25?Gy and 1.21?Gy, the α parameters of 0.13?Gy -1 and 0.29?Gy -1 , and the SF_2 parameters of 0.765 and 0.326, respectively. The CNE2-pNeo and CNE2-wtp53 cells had the D_0 parameters of 0.92?Gy and 0.84?Gy, the Dq parameters of 1.45?Gy and 1.04?Gy, the α parameters of 0.13?Gy -1 and 0.76?Gy -1 , and the SF_2 parameters of 0.675 and 0.156, respectively. Compared with nasopharyngeal carcinoma cells with p53 dysfunction, decreased D_0, Dq, SF_2 and increased α were seen in wild-type p53 transfected cells after radiation. Conclusion Wild-type p53 gene could enhance the radiosensitivity of nasophayngeal carcinoma cell lines with abnormal p53 function." @default.
- W2392472402 created "2016-06-24" @default.
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- W2392472402 date "2005-01-01" @default.
- W2392472402 modified "2023-09-28" @default.
- W2392472402 title "Radiobiological characteristics of the nasopharyngeal carcinoma cell lines in different p53 function status" @default.
- W2392472402 hasPublicationYear "2005" @default.
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