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- W2392479043 abstract "Objective To investigate the antitumor mechanisms of whole peptidoglycan(WPG) of bifidobaeteria bifidum in view of the signal transduction. Methods Nude mouse model of transplanted tumor of colorectal carcinoma was established and treated by intraperitoneal injection of WPG. The activity of protein tyrosine kinases(PTK), protein kinase C(PKC)α, βⅠ, βⅡ, γ, e, ζ and the density of positive nuclear factor-κB(NF-κB) cell in transplanted tumors were measured. Results After treatment with WPG, the activity of PTK、average fluorescent strength of PKCα and density of positive NF-κB cell in transplanted tumors were significanfiy lower than those in untreatment control group(P0.01). There was no difference in the average fluorescent strength of PKC βⅠ, βⅡ, γ, e, ζ between the two groups (P0.05). Conclusions WPG of bifidobacteria bifidum could markedly decrease the activity of PTK and PKCα, and inhibit the activation of NF-κB of colorectal in vivo." @default.
- W2392479043 created "2016-06-24" @default.
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- W2392479043 date "2003-01-01" @default.
- W2392479043 modified "2023-09-23" @default.
- W2392479043 title "Influence of whole peptidoglycan of bifidobacteria on signal transduction of experimental colorectal carcinoma" @default.
- W2392479043 hasPublicationYear "2003" @default.
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