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- W2392499765 abstract "Objective To detect and analyze the thioredoxin reductase(TrxR) activity and the expression of cleaved caspase-3 in hippocampus of seizure rats induced by kainic acid(KA).Methods Adult male Sprague-Daley rats were allotted into 2 groups as followed :control group(NS) and seizure group(KA).Seizures were induced by intracerebroventricular injection of KA dissolved in sterile saline.TrxR activity was detected by dithio-bis-nitrobenzoic acid reduction assay.Western blotting was used to analyze the expression of cleaved caspase-3.Results Thioredoxin reductase activity were(71±19)U/mg,(116±40)U/mg respectively.Compared with the control group,the expression of cleaved caspase-3 increased significantly in the seizure group(P0.05).Conclusion TrxR activity increases in hippocampus of seizure rats induced by KA,subsequently activates caspase-3 and ultimately results in neuronal apoptosis." @default.
- W2392499765 created "2016-06-24" @default.
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- W2392499765 date "2011-01-01" @default.
- W2392499765 modified "2023-09-23" @default.
- W2392499765 title "Detection of thioredoxin reductase activity and the expression of cleaved caspase-3 in hippocampus of seizure rats" @default.
- W2392499765 hasPublicationYear "2011" @default.
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