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- W2392504294 abstract "Aim To investigate whether systemic or local(culprit artery) plasma alpha-defensin 1-3(DEFA1-3) levels are associated with stable coronary artery disease(CAD) and acute ST-segment elevation myocardial infarction(STEMI).Methods Systemic or local blood samples were obtained from 122 consecutive male subjects including no CAD(n=31) controls,stable CAD(n=44) and STEMI(n=47).Plasma DEFA1-3 levels were measured by ready-to-use solid-phase enzyme-linked immunosorbent assay(ELISA) based on the sandwich principle.Results Systemic DEFA1-3 in STEMI were increased compared with no CAD(P0.05) and stable CAD(P0.05),and systemic DEFA1-3 in stable CAD were higher than in no CAD(P0.05).However,local and systemic levels of DEFA1-3 did not differ(P0.05).Receiver operating characteristic(ROC) analysis revealed that the best cutoff value for systemic DEFA1-3 levels discriminating STEMI from no CAD and stable CAD was 136.3 μg/L with a sensitivity of 77.2%,a specificity of 66.7% and an area under the curve(AUC) of 0.717(95%CI: 0.624 to 0.811,P=0.000).Conclusion STEMI was associated with increased DEFA1-3 in systemic circulation.Future studies should be directed to their prognostic values for myocardial infarction." @default.
- W2392504294 created "2016-06-24" @default.
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- W2392504294 date "2012-01-01" @default.
- W2392504294 modified "2023-09-25" @default.
- W2392504294 title "Level Change of Local and Systemic Plasma Alpha-Defensin 1-3 in Acute Myocardial Infarction" @default.
- W2392504294 hasPublicationYear "2012" @default.
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