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- W2392507275 abstract "Objective: To study the pharmaceutical characteristics of freeze-dried cyclosporine A-Eudragit S100 nanoparticles(CyA-S100-NP)in dogs.Methods: A random and two-way crossover study was adopted in 6 dogs.The blood concentration was determined by internal standard HPLC method after oral administration of CyA-S100-NP and Neoral.Pharmacokinetics parameters were calculated using 3P97 program.Results: The concentration-time data were fitted as a two-compartment open model.The AUC of CyA-S100-NP was higher than that of Neoral(P0.05),while the CL significantly decreased(P0.05).The relative bioavailability of CyA-S100-NP was 135.9% as compared with Neoral.Conclusion: The bioavailability of CyA in CyA-S100-NP is significantly improved.CyA-S100-NP has the potential to develop a new CyA nanoparticle solid formulation." @default.
- W2392507275 created "2016-06-24" @default.
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- W2392507275 date "2010-01-01" @default.
- W2392507275 modified "2023-09-23" @default.
- W2392507275 title "Pharmacokinetic profile of freeze-dried cyclosporine A-Eudragit S100 nanoparticle formulation in dogs" @default.
- W2392507275 hasPublicationYear "2010" @default.
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