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- W2392509780 abstract "Objective: To investigate the effects of BZL Decoction on fatty deposition and on LKB1-AMPK-ACC signal pathway of hepatic lipotoxicity model in vitro, and to explore the mechanism of BZL Decoction on preventing and treating nonalcoholic fatty liver disease(NAFLD). Methods: The steatosis modeling of HepG2 cells were induced by free fatty acid(FFA). HepG2 cells were divided into a control group, a model group and treatment groups. Treatment groups were administrated with different concentrations of BZL Decoction contained serum. The contents of TG in cells were measured. The pathological changes of cells were observe by oil-red O staining. The P-LKB1, P-AMPK, P-ACC protein expression and LKB1, AMPKα, ACC expression were measured respectively. Results: After stimulated with FFA for 24 hours, model group showed remarkable deposition of lipid. Compared with the control group, the content of TG in model group was much higher(P0.01). All of the protein expression of P-LKB1, P-AMPK and P-ACC significantly decreased, and all of mRNA expression of LKB1,AMPK and ACC significantly decreased. Compared with the content of TG in the model group, the content of TG in high-doze BZL Decoction group was much lower(P0.01), and the deposition of lipid was much lower. Compared with the model group, all of the protein expression of P-LKB1, P-AMPK and P-ACC in treatment groups significantly increased, and all of mRNA expression of LKB1, AMPK and ACC significantly increased(P0.05, P0.01). Conclusion: BZL Decoction can significantly inhibit thefatty deposition in HepG2 cells induced by FFA. The ef ect is in dose-dependent manner. To activate LKB1-AMPK-ACC signal pathway might be one of the most important mechanisms of BZL Decoction's prevention and treatment of NAFLD." @default.
- W2392509780 created "2016-06-24" @default.
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- W2392509780 date "2014-01-01" @default.
- W2392509780 modified "2023-09-22" @default.
- W2392509780 title "Effects of BZL Decoction on fatty deposition in HepG2 cells induced by free fatty acid and on LKB1-AMPK-ACC signal pathway" @default.
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