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- W2392531889 abstract "Objective To investigate the influence of the hemopexin on the formation of venous thrombosis in patients underwent total hip replacement(THR). Methods Forty THR patients were randomly divided into two groups with 20 cases each.The patients in hemopexin group were given hemopexin 1 KU intramuscularly and 1 KU intravenously 5min before operation.Those in control group were injected normal saline instead of hemopexin as the controls. Venous blood samples were taken before drug injection,at 60 and 120min after that for the measurements of D-dimer (D-D),activity of anticoagulation(AT),prothrombin time(PT),activated partial thromboplastin time(APTT),tissue-plasminogen activator(tPA-Ag) and plasminogen activator inhibitortor(PAI-1).All patients were received the vascular ultrasound examination on the both lower extremities at the same time points.Results The venous thrombosis occurred in 3 to 10 days after operation was found by vascular ultrasound in 5 cases (25.0%) in hemopexin group and 6 cases (30.0%) in control group. tPA-Ag at 60min after hemopexin was significantly higher in hemopexin group than that in control group (P0.05).Conclusion The application of hemopexin in THR patients has no significant impact on the coagulation function and does not increase the incidence of venous thrombosis,but may increase the activity of plasminogen." @default.
- W2392531889 created "2016-06-24" @default.
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- W2392531889 date "2009-01-01" @default.
- W2392531889 modified "2023-09-24" @default.
- W2392531889 title "Effects of hemopexin on venous thrombosis in patients underwent artificial hip replacement" @default.
- W2392531889 hasPublicationYear "2009" @default.
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