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- W2392534461 abstract "Objective To determine the effect of intravascular administration of prostaglandin E1(PGE1) on myocardial angiogenesis and the expression of vascular endothelial growth factor(VEGF) in rats with acute myocardial infarction,and the relationship between the dose of intravascular administration of PGE1 and the effect of expression of VEGF in rat cardiac myocytes.Methods Left anterior descending coronary arteries were ligated in SD rats after anesthesia by 10% pentobarbital sodium.Treatment group was given various doses of PGE1 intravenously for 2 and 4 weeks while the control group and the sham-operation group were given normal saline(NS) intravenously at the same time.All the rats were killed and the heart specimen were fixed by 10% formalin,sectioned and colorated by means of HE staining and immunohistochemical staining to observe VEGF and CD34 through microscope,which were quantified with the help of computer assisted morphometry.The levels of VEGF in plasma were measured before experiment,2 and 4 weeks after experiment by enzyme-linked immuno-sorbent assay(ELISA) respectively.Results PGE1 treated group had significantly higher levels of VEGF protein expression in the myocardium as compared to the control group and the sham-operation group(all P(0.05).) Meanwhile there was a significant increase in the number of capillaries in the PGE1 treated group when compared with the other 2 groups(all P0.05).The VEGF producing in cardiac myocytes increased responsively with the increase of the dose of intravascular administration of PGE1.But there was no significant difference in the number of capillaries among PGE1-treated subgroups.Conclusions PGE1 can increase the excretion of VEGF and the number of capillaries,and enhance collateral circulation of the occluded coronary.PGE1 can stimulate the expression and excretion of VEGF in cardiac myocytes in a dose-dependent manner." @default.
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- W2392534461 date "2006-01-01" @default.
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- W2392534461 title "Effects of PGE1 on the expression of VEGF in rat cardiac myocytes and dose-effect relationship between PGE1 and the expression of VEGF" @default.
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