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- W2392536634 abstract "Objective To investigate the inhibitory effects of adenovirus-mediated PML growth suppressor on growth of gallbladder carcinoma cells.Methods Transduction efficiency of PML gene was tested by in situ hybridization(ISH).PML mRNA and PML protein expression after Ad-PML infection was examined by means of ISH and imunohistochemistry.Gallbladder carcinoma cells(GBC-SD) were placed in 24-well tissue culture plates,and infection was carried out with Ad-PML or Ad-control.The material was analyzed by MTT assay. GBC-SD cells infected by wither Ad-PML or Ad-control and positive control were resuspended,and the cell suspension was subcutaneously injected into the nude mice.Tumor formation was evaluated at the end of a 1-month period after the injection,and the tumor volume and weight were determined.Results The maximal transduction efficiency of PML was obtained at a concentration of 100 MOI.The Ad-PML-infected cells expressed a high level of PML mRNA and protein.A detectable level of PML was found on day 15 after viral infection.The growth rate of the Ad-PML-infected GBC-SD cells was significantly inhibited,and the Ad-PML-treated GBC-SD cells failed to form tumors in nude mice.Conclusions PML gene is highly and stably expressed in Ad-PML-infected GBC-SD cells.PML is able to suppress growth in vitro and tumorigenicity of human gallbladder carcinoma cells in nude mice.Ad-PML may be a potential candidate for gene therapy of human gallbladder carcinoma." @default.
- W2392536634 created "2016-06-24" @default.
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- W2392536634 date "2005-01-01" @default.
- W2392536634 modified "2023-09-23" @default.
- W2392536634 title "Adenovirus-mediated PML growth suppressor in gene therapy of gallbladder carcinoma" @default.
- W2392536634 hasPublicationYear "2005" @default.
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