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- W2392545887 abstract "Objective To investigate the mechanism of the anticancer action of vinorelbine combinated with radiation on human breast cancer cell line MCF-7. Methods The MTT method was applied to examine the growth inhibition of MCF-7 treated with vinorelbine. The cell cycle distribution and apoptosis index(AI) were analysed by flow cytometry. The morphology of the MCF-7 cells apoptosis was observed by transmission electron microscopy. Results The MTT result showed the IC 50 of vinorelbine for 24 h was 7.20 μg/ml. Cell cycle analysis showed the four groups have the different cell cycle distribution. In control group, many cells were in the G 1～S phase; in vinorelbine group, the percentage of the cell population in G 2/M was significantly different from that of control group or radiation group (P0.05).The apoptotic indexes(AI) of MCF-7 of four groups showed: The mean AI at different time of radiation group, vinorelbine group and vinorelbine plus radiation group were 2.98±3.90%,8.01±1.87%,15.57±5.23%, the AI of (V+R) group was significantly different from that in the vinorelbine group or radiation group (P0.05).Transmission electronmicroscope can detect condensed chromatin, nuclear fragmentation and apoptotic body of MCF-7 cells.Conclusion Vinorelbine can inhibit the growth of human breast cancer cell line MCF-7. It can cause accumulation of MCF-7 cells in the G 2/M phase of the cell cycle, and can induce its apoptosis. Vinorelbine pretreatment before radiation can potentiate the effects of radiation and apoptosis induced by radiation." @default.
- W2392545887 created "2016-06-24" @default.
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- W2392545887 date "2002-01-01" @default.
- W2392545887 modified "2023-09-23" @default.
- W2392545887 title "Studies on Effects of Vinorelbine Plus Radiation on Human Breast Cancer Cell Line MCF-7" @default.
- W2392545887 hasPublicationYear "2002" @default.
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