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- W2392546114 abstract "Objective To explore the relationship of inflammation mediator leukotriene E4(LTE4) and nocturnal asthma in 3-6 years old children.Methods The subjects were divided into 3 groups:nocturnal asthmatic group (n=20),non-nocturnal attacks group (n=20) and normal control group(n=10).Urine were collected at 0901-1500,1501-2100 and 2101-0900 in the subjects,respectively.Urinary LTE4 was measured by eneyme linked immunosorbent assay (ELISA).SPSS 11.0 software was used to analyze data.Results In nocturnal asthmatic group,the level of LTE4 had obvious circadian rhythm,the level of LTE4 was highest at 2101-0900 and lowest at 0901-1500,there was significant difference(P0.01),the level of LTE4 at 2101-0900 was significantly higher than that at 15:01-21:00(P0.05),the level of LTE4 at 1501-2100 was significantly higher than that at 0901-1500(P0.05).There were no significant differences in non-nocturnal attacks group (Pa0.05).At 2101-0900,the level of LTE4 was significantly higher in nocturnal asthmatic group than those in non-nocturnal attacks group and normal control group(P0.05,0.01).At 0901-1500,1501-2100 and 2101-0900,the levels of LTE4 were significantly higher in nocturnal asthmatic group and non-nocturnal attacks group than that in normal control group(Pa0.01).Conclusions In nocturnal asthmatic children who are 3-6 years old,urinary LTE4 takes on circadian rhythm.LTE4 is a significant inflammation mediator in asthma,and may contribute to the nocturnal worsening of asthma.Detecting in dynamic state urinary LTE4 is an index in diagnosing nocturnal asthma ,there is significance in evaluating noctunal asthmatic attack,effect and prognosis in below 6 years." @default.
- W2392546114 created "2016-06-24" @default.
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- W2392546114 date "2008-01-01" @default.
- W2392546114 modified "2023-09-28" @default.
- W2392546114 title "Circadian Rhythm of Urinary Leukotriene E4 in 3-6 Years Old Children with Nocturnal Asthma" @default.
- W2392546114 hasPublicationYear "2008" @default.
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