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- W2392579969 abstract "Objective: To investigate the effects of acid sensing ion channels(ASICs) blocker on injury of ischemic cerebral oxidative stress in rats.Methods: The model of focal cerebral ischemia/reperfusion(I/R) in Sprague-Dawley(SD) rats was established with sutured-occluded method invented by Zea Longa.Thirty-two SD rats were randomly divided into four groups including sham operated,I/R model,amiloride Ⅰ and amiloride Ⅱ group,and each group were eight rats.The rats were randomly taken for HE tissue stain from freezing brain slices and determination to contents of MPO and NO from the other brain tissue homogenized by biochemical reagents at twenty-four hours reperfusion after two hours focal brain ischemia.Results: Compared with I/R model group,the contents of MPO and NO were significantly higher in amiloride Ⅰ and amiloride Ⅱ group(P0.05),and the amiloride Ⅰ group was higher than amiloride Ⅱ(P0/05)/ Conclusion: ASICs blocker amiloride could have neuroprotective effects by inhibiting oxidative stress in ischemic injury and its mechanisms of neuroprotection was chiefly because amiloride blocks ASICs that results in alleviating Ca2+ overloaded.Amiloride was of dose-effect relationship." @default.
- W2392579969 created "2016-06-24" @default.
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- W2392579969 date "2007-01-01" @default.
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- W2392579969 title "Protective effects of ASICs blocker on cerebral ischemia/reperfusion in rats" @default.
- W2392579969 hasPublicationYear "2007" @default.
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