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- W2392581807 abstract "Objective To investigate the gene expression of quorum sensing(QS) systems and active efflux pump MexAB-OprM in clinical multidrug resistant Pseudomonas aeruginosa and analyze the association with antibiotic resistance.Method Clinical isolates of Pseudomonas aeruginosa were collected in Suzhou municipal hospital and Shanghai Jiangwan hospital from February to June,2011.The bacterial biofilm forming ability was detected by quantitative assay;bacterial antibiotic resistance was detected by minimum inhibitory concentration(MIC) method;lasI,lasR genes of quorum sensing system and mexA gene of active efflux pump system were analysed by using a multiplex polymerase chain reaction(PCR);Quantitative real-time polymerase chain reaction was performed to measure mRNA expression of genes lasI,lasR and mexA.Result There were 58 biofilm-producing Pseudomonas aeruginosa strains and 24 multidrug-resistant Pseudomonas aeruginosa strains in the 84 clinical isolates,accounting for 69% and 28.6%,respectively.Among the 24 multidrug-resistant strains,11(45.8%) were biofilm-producing bacteria.18 strains(75%) had up-regulated expression of mexA and 8 strains(33.3%) had upregulated expression of lasI.Conclusion The biofilm formation of multiple drug-resistant Pseudomonas aeruginosa strains are significantly lower than that of non-multiple drug-resistant strains.The expression of active efflux pump MexAB-OprM gene is significantly up-regulated in multiple drug-resistant Pseudomonas aeruginosa.The expression of lasI gene in biofilm-producing bacteria is significantly increased while no obvious change in that of lasR gene." @default.
- W2392581807 created "2016-06-24" @default.
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- W2392581807 date "2011-01-01" @default.
- W2392581807 modified "2023-09-25" @default.
- W2392581807 title "Gene expression of quorum sensing system and active efflux gene in clinical multidrug resistant Pseudomonas aeruginosa" @default.
- W2392581807 hasPublicationYear "2011" @default.
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