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- W2392586784 abstract "Aim: To investigate whether the tissue plasminogen activator(TPA)-7351C/T enhancer polymorphism correlated with the risk of cerebral infarction or not. Methods: Genotype of TPA-7351C/T was determined in 157 patients with cerebral infarction and 169 controls by polymerase chain reaction and sequencing. After adjusted for known cerebrovascular risk factors, the relationship between genetic poly- morphisms of TPA-7351C/T and the susceptibility of cerebral infarction was estimated by using unconditional Logistic regression. Results:The genotypes of C/C, C/T and T/T were 42%, 45% and 13% in cerebral infarction patients,and were 44%, 47% and 9% in controls. After adjustment for hypertension, diabetes mellitus and atrial fibrillation, individuals who had T/T genotypes increased risk of developing cerebral infarction compared with those with C/C genotypes (P0.05). Stratification for stroke subtype showed a significant association between the T/T genotype and lacunar stroke(P0.05). Conclusion: The TPA- 7351C/T polymorphisms might be associated with the risk of lacunar stroke ." @default.
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- W2392586784 date "2008-01-01" @default.
- W2392586784 modified "2023-09-23" @default.
- W2392586784 title "The Study of Tissue Plasminogen Activator-7351C/T Enhancer Polymorphism on the Risk of Cerebral Infarction" @default.
- W2392586784 hasPublicationYear "2008" @default.
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