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- W2392603755 abstract "Objective To study the combined toxicity effect of exposure to formaldehyde and toluene on neurobehavior of mice.Methods Seventy-two healthy clean Kunming mice were randomly divided into 9 groups,the control group(0 mg/m3 formaldehyde +0 mg/m3 toluene),the formaldehyde group(1,5 mg/m3),the toluene group(400,2 000 mg/m3),the combined groups(1 mg/m3 formaldehyde +400 mg/m3 toluene,1 mg/m3 formaldehyde +2 000 mg/m3 toluene,5 mg/m3 formaldehyde +400 mg/m3 toluene,5 mg/m3 formaldehyde +2 000 mg/m3 toluene).3×3 factorial analysis was used in the experiment.The treatments were conducted by static inhaling formaldehyde or(and) toluene,two hours per day for 14 consecutive days.After 14 days of exposure,the behavior of mice was tested by Morris water maze and open field test.Results In space training and learning experiment,the escape latency of all groups increased as the exposure dose increased and decreased as the days of training increased.In space exploration experiment,the time of finding the platform presented an ascend tendency,while the time and the percentage of swimming distance in target quadrant presented a descend tendency(P0.01).There is interaction between formaldehyde and toluene in the time of finding the platform and swimming in target quadrant(P0.05).The results of open-field test showed the latency presented an ascend tendency,the number of crossing pane,standing and modifying presented a descend tendency(P0.01).There was interaction between formaldehyde and toluene in latency,the number of crossing pane and standing(P0.05).Conclusion Formaldehyde and toluene may degrade the learning and memory abilities of mice.Maybe the joint neurotoxicity of formaldehyde and toluene is synergistic." @default.
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- W2392603755 date "2010-01-01" @default.
- W2392603755 modified "2023-09-23" @default.
- W2392603755 title "Effect of joint exposure to formaldehyde and toluene on neurobehavior of mice." @default.
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