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- W2392606911 abstract "[Objective] To explore the expression of the cardiac Heat Shock Protein 72 (HSP72) induced by Dexamethasone(DEX) pretreatment and its effects on ischemia/reperfusion injury in Spraque-Dawley rats heart. [Methods] The rats were pretreated with DEX before their hearts were separated for perfusion and for mimic ischemia/reperfusion, sodium chloride served as control. HSP72 was examined by using western blotting. The left ventricular functions and reperfusion arrhythmias were observed dynamically before ischemia and after 60 minute reperfusion following 30 minute ischemia. The hearts were perfused with TTC after 60 minute reperfusion. The myocardial infarct sizes were measured through Adobe Photoshop. The total amounts of CK-MB were analyzed by chemical methods. [Results] Compared with control group, the expression of HSP72 was significantly increased (P 0.05), the left ventricular functions (±dp/dtmax) were greatly improved (P 0.01), the accumulated point of ventricular arrhythmia was significantly reduced (P 0.01), and the infarct size was significantly reduced (P 0.01). Moreover, the total amount of CK-MB was significantly decreased (P 0.05). [Conclusions] As a novel inducer of HSP72, DEX induces upregulation of HSP72, which functions to attenuate ischemia/reperfusion injury in rats heart." @default.
- W2392606911 created "2016-06-24" @default.
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- W2392606911 date "2008-01-01" @default.
- W2392606911 modified "2023-09-25" @default.
- W2392606911 title "Heat Shock Protein 72 induced by Dexamethasone attenuates ischemia/reperfusion injury in rats heart" @default.
- W2392606911 hasPublicationYear "2008" @default.
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