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- W2392608216 abstract "OBJECTIVE To investigate the efficacy and safety in patients with non-dipper type hypertension after different dosage regimen of bisoprolol treatment.METHODS The patients were randomly divided into two parallel groups.All patients were treated with bisoprolol.The first group took bisoprolol at eight o'clock once-daily between 2.5 mg and 10 mg.The second group took bisoprolol at twenty o'clock once-daily between 2.5 mg and 10 mg.The efficiency of the 8 weeks' treatment and the change of the 24 hours blood pressure,laboratory parameters and adverse events analysis and evaluation of the situation were detected.RESULTS The blood pressures of the patients in both groups decreased(P0.05),but taking bisoprolol at night of the second group had a better efficacy than that in the first group.In the second group patients taking bisoprolol at night,their 06:00-09:00 and 21:00-24:00 of blood pressure control rate was significantly increased as compared with the morning medication group.The blood and liver and kidney functions of the two groups of patients showed no significant adverse reactions.The adverse events occurred in 3 cases,the statistics of the incidence of adverse events between the two groups was no significant difference.CONCLUSION Both dosage regimens of treatment can control the blood pressure with good safety and efficacy,but taking drug at twenty o'clock was better for the non-dippers hypertension and the diurnal rhythm of blood pressure than taking at eight o'clock." @default.
- W2392608216 created "2016-06-24" @default.
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- W2392608216 date "2011-01-01" @default.
- W2392608216 modified "2023-09-24" @default.
- W2392608216 title "Change of 24 h ambulatory blood pressure and safety in patients with hypertension after different dosage regimen of bisoprolol" @default.
- W2392608216 hasPublicationYear "2011" @default.
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