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- W2392624018 abstract "Objective:To investigate plasma contents of β-endorphin(β-EP) in patients with coronary heart disease(CHD) and study the relationship between myocardial function and β-EP in these patients.Methods:At 12,24,48,and 96 h and 7 d after episode,the plasma levels of β-EP were measured by immunoradiometric assay(IRMA).The left ventricular ejection fraction(LVEF) was measured with echocardiography and the class of cardiac function was assessed according to NYHA. Results:The plasma levels of β-EP in 58 patients with CHD were higher than those in 20 healthy subjects(P0.05).It increased within 12 h after episode,peaked at 24 h [(104.2±30.1) ng/L in acute myocardial infarction group and(42.7±11.4) ng/L in angina pectoris group] and fell-off in a week.The levels of β-EP in patients with heart failure increased more than those with normal heart function.The levels of β-EP in patients with Ⅰ,Ⅱ,Ⅲ and Ⅳ class of heart function were(47.0±14.9) ng/L,(56.8±18.0)ng/L,(89.7±24.6)ng/L and(121.2±22.2)ng/L respectively.The plasma levels of β-EP had significant negative correlation with LVEF (r=-0.22,P0.05). Conclusion:Peaking at 24 h after episode in patients with CHD,the plasma level of β-EP is related to the heart function.It might be a valuable laboratory plasma marker for diagnosis of the systolic function of CHD patients." @default.
- W2392624018 created "2016-06-24" @default.
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- W2392624018 date "2007-01-01" @default.
- W2392624018 modified "2023-09-25" @default.
- W2392624018 title "Clinical study of the relationship between myocardial function and plasma β endorphin in the patients with coronary heart disease" @default.
- W2392624018 hasPublicationYear "2007" @default.
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