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- W2392647263 abstract "Objective To establish the model of visceral hyperalgesia in young rats.To explore the role of abnormal expression of calcitonin gene related peptide(CGRP)in forming the visceral hyperalgesia in young rats.Methods Eight-day-old Sprague-Dawley rats were divided into four groups(n = 8 for each):rats of group A1B1 were imposed on colorectal irritation(CI)at neonatal period and imposed on colorectal distension(CRD)at 6-week age;rats of group A1B2 were imposed on CI at neonatal period and without being imposed on CRD at 6-week age;rats of group A2B1 were not impose on CI at neonatal period and were imposed on CRD at 6-week age;rats of group A2B2 were neither imposed on CI at neonatal period nor CRD at 6-week age.Group A1B1 and group A1B2 were treated with CI once a day for 7 consecutive days from the 8th day after birth.Conventionally breeding till the young period(6-week age),the visceral sensitivity of group A1B1 and group A1B2 was evaluated.Then,SABC immunohistochemical assay was used to detect the expression of CGRP in spinal cord of all rats in four groups.Results The amplitudes of spike EOMA increased gradually with the rising of the CRD pressure in young rats.When the CRD pressure were 15 mmHg,30 mmHg,45 mmHg and 60 mmHg,the spikes were significantly higher in the group A1B1 than group A2B1.When pressure were 75 mmHg,the differences were not statistically significant.Rats accepted CI in neonatal period and noxious stimulation of CRD could make the number of CGRP-like immunoreactivity increased in the spinal cord of young rat.Conclusions The persistent CI in neonatal period can result in low pain threshold and chronic high visceral pain sensibility in developing rats.Rats with abnormal chronic visceral pain may involve the abnormal expressing of CGRP in spinal cord.CGRP as a neurotransmitter,may involve in the changing of visceral pain sensitivity." @default.
- W2392647263 created "2016-06-24" @default.
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- W2392647263 date "2011-01-01" @default.
- W2392647263 modified "2023-09-22" @default.
- W2392647263 title "Relationship between visceral hyperalgesia in young rats and the expression of CGRP in spinal cord" @default.
- W2392647263 hasPublicationYear "2011" @default.
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