Matches in SemOpenAlex for { <https://semopenalex.org/work/W2392649286> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2392649286 abstract "Objective:To explore the effects of peroxisome proliferator-actived receptors-γ(PPAR-γ)agonists rosiglitazone and non-steroidal anti-inflammatory drugs(NSAIDs) ibuprofen on tumor necrosis factor-α(TNF-α)mRNA expression in the brain of rats with acute experimental autoimmune encephalomyelitis(EAE).Methods:EAE models on rat were established by inoculating the homogenate containing spinal cord of guinea pig and complete Freund's adjuvant,and then treated by rosiglitazone and ibuprofen respectively.The improvement of clinical manifestations was assessed to determine the curative effect of the two medicines and TNF-α mRNA expression level was detected by RT-PCR.Results:Compared with EAE group,the groups with rosiglitazone and ibuprofen showed improvement in clinical manifestations ,and the expression of TNF-α mRNA reduced markedly(P0.01).Other index of the treated groups were no significantly different(P0.05).Conclusions:PPAR-γ agonists rosiglitazone and NSAIDs ibuprofen could obviusely improve the clinical manifestations of EAE rats,and decrease the level of the expression of TNF-α mRNA,which suggested PPAR-γ agonists may have the anti-inflammation neural protective function on EAE or multiple sclerosis(MS),and the anti-inflammation of ibuprofen may be related to the activation of PPAR-γ." @default.
- W2392649286 created "2016-06-24" @default.
- W2392649286 creator A5009031026 @default.
- W2392649286 date "2007-01-01" @default.
- W2392649286 modified "2023-09-24" @default.
- W2392649286 title "Effects of peroxisome proliferator-actived receptors-γ agonists on tumor necrosis factor-α expression in rats with acute experimental autoimmune encephalomyelitis" @default.
- W2392649286 hasPublicationYear "2007" @default.
- W2392649286 type Work @default.
- W2392649286 sameAs 2392649286 @default.
- W2392649286 citedByCount "0" @default.
- W2392649286 crossrefType "journal-article" @default.
- W2392649286 hasAuthorship W2392649286A5009031026 @default.
- W2392649286 hasConcept C126322002 @default.
- W2392649286 hasConcept C134018914 @default.
- W2392649286 hasConcept C170493617 @default.
- W2392649286 hasConcept C17991360 @default.
- W2392649286 hasConcept C187345961 @default.
- W2392649286 hasConcept C203014093 @default.
- W2392649286 hasConcept C2776914184 @default.
- W2392649286 hasConcept C2778486448 @default.
- W2392649286 hasConcept C2779944601 @default.
- W2392649286 hasConcept C2780152017 @default.
- W2392649286 hasConcept C2780640218 @default.
- W2392649286 hasConcept C71924100 @default.
- W2392649286 hasConcept C98274493 @default.
- W2392649286 hasConceptScore W2392649286C126322002 @default.
- W2392649286 hasConceptScore W2392649286C134018914 @default.
- W2392649286 hasConceptScore W2392649286C170493617 @default.
- W2392649286 hasConceptScore W2392649286C17991360 @default.
- W2392649286 hasConceptScore W2392649286C187345961 @default.
- W2392649286 hasConceptScore W2392649286C203014093 @default.
- W2392649286 hasConceptScore W2392649286C2776914184 @default.
- W2392649286 hasConceptScore W2392649286C2778486448 @default.
- W2392649286 hasConceptScore W2392649286C2779944601 @default.
- W2392649286 hasConceptScore W2392649286C2780152017 @default.
- W2392649286 hasConceptScore W2392649286C2780640218 @default.
- W2392649286 hasConceptScore W2392649286C71924100 @default.
- W2392649286 hasConceptScore W2392649286C98274493 @default.
- W2392649286 hasLocation W23926492861 @default.
- W2392649286 hasOpenAccess W2392649286 @default.
- W2392649286 hasPrimaryLocation W23926492861 @default.
- W2392649286 hasRelatedWork W172006844 @default.
- W2392649286 hasRelatedWork W1963764925 @default.
- W2392649286 hasRelatedWork W1970081884 @default.
- W2392649286 hasRelatedWork W2012242139 @default.
- W2392649286 hasRelatedWork W2070911153 @default.
- W2392649286 hasRelatedWork W2106942332 @default.
- W2392649286 hasRelatedWork W2132975915 @default.
- W2392649286 hasRelatedWork W2329200458 @default.
- W2392649286 hasRelatedWork W2334492386 @default.
- W2392649286 hasRelatedWork W2353203232 @default.
- W2392649286 hasRelatedWork W2357901664 @default.
- W2392649286 hasRelatedWork W2371883650 @default.
- W2392649286 hasRelatedWork W2374768916 @default.
- W2392649286 hasRelatedWork W2375529300 @default.
- W2392649286 hasRelatedWork W2382859194 @default.
- W2392649286 hasRelatedWork W2390194603 @default.
- W2392649286 hasRelatedWork W266117108 @default.
- W2392649286 hasRelatedWork W3028987695 @default.
- W2392649286 hasRelatedWork W3100201155 @default.
- W2392649286 hasRelatedWork W2785769210 @default.
- W2392649286 isParatext "false" @default.
- W2392649286 isRetracted "false" @default.
- W2392649286 magId "2392649286" @default.
- W2392649286 workType "article" @default.