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- W2392662009 abstract "Objective:Anemia is a common complication in patients with multiple myeloma (MM) and occurs in more than two thirds of all patients. Red blood cell (RBC) transfusions is usually administrated clinically. Although recombinant human erythropoietin (rHuEPO) has showed the effectiveness in MM patients with anemia, there is no conclusion in the administration dosage and continuing time. To observe the effects of high dose rHuEPO on MM patients with anemia. Methods: Eighty-seven cases who were diagnosed as MM with anemia, were initially given rHuEPO at 40 000 U subcutaneously per day for five days and then at 40 000 U per week. Meanwhile,one kind of chalybeate was administrated interruptablly. 90 controls who were selected from hospitalized MM patients during the same month, received blood transfusion when their hemoglobin(Hb) levels were lower than 60 g/L or they have manifestated a significant anemic symptoms so as to keep the Hb levels of most controls more than 80 g/L-100 g/L. At the same time, the chemotherapy schemes for the two groups were not limited. The observed period is six months. Results: For the case group(rHuEPO group), Hb levels began to elevate at 2 weeks and the median response time is 16 days;those Hb levels could achieve normal level during 1.5 and 2 months and the median time is 51 days after rHuEPO has been used.The index number of living happiness(INLH) for rHuEPO group is significantly better than that of control group (transfusion group): 69.27±3.18 vs 58.35±2.89(P0.05) and 72.16±2.83 vs 57.76±3.24(P0.01) respectively at three and six months after entering research. At the research endpoint, the average direct cost of rHuEPO group for each case is 10 754.40 RMB, which is obviously less than 20 704.20 RMB of transfusions group at the same effectiveness. Conclusion: The high dose rHuEPO displayed the better effects, the fewer response time, the more significant improvement of INLH and the lower cost than blood transfusion on MM patients with anemia." @default.
- W2392662009 created "2016-06-24" @default.
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- W2392662009 date "2009-01-01" @default.
- W2392662009 modified "2023-09-27" @default.
- W2392662009 title "The Administration of High-dose Recombinant Human Erythropoietin in Multiple Myeloma Patients with Anemia" @default.
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