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- W2392665823 abstract "AIM:To compare the antitumor effects and toxicity of 5-fluorouracil polyphase liposome (Co-5-FU)with 5-fluorouracil(5-FU)in sarcoma 180 tumor-bearing mice.METHODS:The models of solid tumors were produced by intradermal injection of sarcoma 180 cells on the back skin and ascite tumors were established by intraperitoneal injection of sarcoma 180 cells in mice.Seventy mice were randomized into 7 groups and were treated with intraperitoneal injection of Co-5-FU(40 mg·kg~(-1),20 mg·kg~(-1),10 mg·kg~(-1) or 5-FU(40 mg·kg~(-1),20 mg·kg~(-1),10 mg·kg~(-1),respectively.Mice in normal control group were treated with normal saline.The inhibitory rate of solid tumors and the survival ratio of ascite tumors were calculated.The toxicity of Co-5-FU and 5-FU were evaluated by biochemical and pathological examination.RESULTS:The inhibitor rates was 48.8 %,39.2 % and 32.0 %(P＜0.01)and the survival ratios was 52.7%,41.4% and 31.9%(P＜0.05)in Co-5-FU group of 40 mg·kg~(-1),20 mg·kg~(-1)and 10 mg·kg~(-1),respectively. Myelosuppression induced by Co-5-FU were less severe than that induced by 5-FU at the same dose(P＜0.05). AST,ALT,ALP and GGT of hepatic enzymes increased in 5-FU group of 40 mg·kg~(-1)(P＜0.05). CONCLUSION:The antitumor effects of Co-5-FU are better than 5-FU and the toxicity of Co-5-FU to heart, liver,kidney and medulla is lower than that of 5-FU at the same dose." @default.
- W2392665823 created "2016-06-24" @default.
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- W2392665823 date "2007-01-01" @default.
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- W2392665823 title "Antitumor effects and toxicity of 5-fluorouracil polyphase liposome in sarcoma 180 tumor-bearing mice" @default.
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