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- W2392683646 abstract "Objective:To investigate the effect of hydrogen sulfide on plasma level of substance P and its relevance to lung inflammation and pulmonary microvascular permeability.Methods: Eight-week old,male Balb/c mice were randomly divided into the following groups: control(saline,i.p.,animals were sacrificed 1h after injection),sodium hydrosulfide(NaHS) at three doses(1,5,or 10 mg·kg-1,i.p.,animals were sacrificed 1h after injection) and NaHS at three time-point(10 mg·kg-1,i.p.,animals were sacrificed 1h,3h,or 6h after injection).Thereafter,plasma substance P level,lung myeloperoxidase(MPO) activity and lung microvascular permeability were measured.On the other hand,preprotachykinin-A(PPT-A) gene knockout mice(PPT-A-/-) and their wild-type mice(PPT-A+/+) were randomly given saline(i.p.) or NaHS(10 mg·kg-1,i.p.).One hour after intervention,mice were sacrificed and lung MPO activity and lung microvascular permeability were examined.Results: Hydrogen sulfide donor drug,NaHS significantly elevated plasma substance P level,lung MPO activity and lung microvascular permeability in a time and dose dependent manner.Deletion of PPT-A gene,the precursor gene for substance P,abolished the elevation in lung MPO activity and lung microvascaular permeability induced by injection of NaHS at a dose of 10 mg·kg-1.Conclusions: Hydrogen sulfide may aggravate lung inflammation and impair lung microvascular permeability via increasing plasma level of substance P." @default.
- W2392683646 created "2016-06-24" @default.
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- W2392683646 date "2010-01-01" @default.
- W2392683646 modified "2023-09-26" @default.
- W2392683646 title "Effect of Hydrogen Sulfide on Circulatory Level of Substance P and Lung Injury in Mice" @default.
- W2392683646 hasPublicationYear "2010" @default.
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