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- W2392697278 abstract "Objective: To observe the expression of STAT3 protein and its phosphorylation by Leptin administration in the cultured hypothalamic cells of newly born SD rats in vitro and elucidate the cellular mechanism of the tyrosine phosphorylation of STAT3 protein in obesity. Methods: The hypothalamic cells were isolated from the newly born SD rats, and cultured with DMEM for 6 days. Then the confluent cells, which had been cultured with serum free DMEM for 24 h, were stimulated by 100ng/ml Leptin for 24 h. The abundance of NSE and the phosphorylation of STAT3 protein was assayed by immunocytochemistry with anti-NSE antibody and anti-phosphor-tyrosine (705) STAT3 antibody. Results: The neurons in neuronal dissociated culture from newly born SD rat hypothalamus in vitro were investigated. During the day 7￣10, the cultured hypothalamic cells grew well and fast, and the cells expressed NSE, but the non-neuron cells were negative. In control group, the expression of STAT3 protein in cultured hypothalamic cell was positive, but phospho-STAT3 protein expression was negative. After Leptin administration for 24 h, the expression of phospho-STAT3 protein was found. Conclusion: For the first time, STAT3 protein phosphorylation were found by the cultured hypothalamic cells with Leptin administration in vitro." @default.
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- W2392697278 date "2006-01-01" @default.
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- W2392697278 title "Effects of recombinant Leptin on the expression of STAT3 protein and its phosphorylation in the cultured hypothalamic cells of newly born SD rats in vitro" @default.
- W2392697278 hasPublicationYear "2006" @default.
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