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- W2392704799 abstract "Objective To explore the kinesis changes of immunologic function in mice infected systemically with Candida albicans(CA).Methods MTT was used to measure ConA-induced spleen lymphocyte proliferation;ELISA was used to detect the levels of IL-18,IL-4,and IFN-γ in the serum;RBC-C3bRR test was used to observe the adhesion ability of erythrocyte.The colony of CA in the left kidney was also counted.Results In these mice infected with Candida Albicans at high or low dose CA,T lymphocyte proliferation activity was enhanced and arrived the normal level at the 7th day.The level of IL-18 sharply decreased at the first day and reached to the normal level at the 7th day.The level of IFN-γ was always higher than that of the normal group and the low immunologic function group.IL-4 decreased 1 day post-infection and was higher than that of the normal group 7 days later.The low dose infecting CA had some stimulus to RBC-C3bRR.The clearance of the high or low dose infecting group has been enhanced as time went by.Conclusion In mice infected with CA at high or low dose,T lymphocyte proliferation activity induced by ConA is enhanced.The immune response against CA is mainly mediated by Th1 in the earlier stage,while the humoral immunity also takes part in the response in the later stage.Low dose CA-infection has some stimulus to RBC-C3bRR.The clearance after high or low dose infecting is enhanced as time goes by." @default.
- W2392704799 created "2016-06-24" @default.
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- W2392704799 date "2008-01-01" @default.
- W2392704799 modified "2023-09-24" @default.
- W2392704799 title "Immunologic function in Balb/c mice infected systemically with Candida albicans" @default.
- W2392704799 hasPublicationYear "2008" @default.
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