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- W2392717963 abstract "Objective: To establish a HPLC analysis method for determination of deoxypodophyllotoxin in rat plasma,and to investigate pharmacokinetic behaviors of deoxypodophyllotoxin polymeric micelles( DPT-PM) in rats after intravenous injection compared with inclusion complex of deoxypodophyllotoxin hydroxypropyl-β-cyclodextrins( DPT-HP-β-CD). Methods: A C18column( 250 mm × 4. 6 mm,5 μm) was used at column temperature of30 ℃,and the mobile phase contained methanol-water( 75∶ 25) with the flow rate of 1. 0 m L·min- 1,and the UV detection wavelength was set at 294 nm. Diazepam was selected as the internal standard. DPT-PM and DPT-HP-β-CD at a dose of 15 mg·kg- 1were iv administered to rats to study the pharmacokinetics. Relationship between the pharmacokinetic parameters and doses( 10,15 and 20 mg·kg- 1) of DPT-PM was studied. Results: The plasma DPT concentration-time profiles after dosing of both preparations were best fitted to the two-compartment model.The CLs of DPT-HP-β-CD and DPT-PM were( 29. 33 ± 5. 18) and( 19. 37 ± 2. 57) m L·kg- 1,and Vssof DPT were( 1. 78 ± 0. 35) and( 1. 00 ± 0. 08) L·kg- 1,respectively. AUC0 ~ ∞following dosing of DPT-HP-β-CD and DPT-PM were( 521. 49 ± 86. 33) and( 783. 08 ± 97. 52) μg·m L- 1·min,respectively. The nonlinear pharmacokinetics existed after iv. administration of DPT-PM at doses of 10,15 and 20 mg·kg- 1. Conclusion: The micelle formulation significantly decreases the plasma clearance of DPT,improves the bioavailability of DPT,and prolongs the blood circulation time of DPT compared with inclusion complex of hydroxypropyl-β-cyclodextrins." @default.
- W2392717963 created "2016-06-24" @default.
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- W2392717963 date "2014-01-01" @default.
- W2392717963 modified "2023-09-23" @default.
- W2392717963 title "Pharmacokinetics of deoxypodophyllotoxin polymeric micelles in rats" @default.
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