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- W2392728725 abstract "Objective To investigate the expression of BMP-7 and TGF-β1 in kidney following ischemia-reperfusion injury in rat and the relationship of them in the injury induced by ischemia-repersion. Methods The ischemia-reperfusion injury model in rat was established with its right kidney excised and left renal artey blocked for 60 minutes.60 SD rats were devided into sham group and experiment group.The renal tissue was observed by optical microscope and the expression of BMP-7 and TGF-β1 were observed by immunohistochemical stain.The expression of BMP-7 and TGF-β1 were measured by image analysis system. Results The expression of BMP-7 decreased makedly at 24 h after reperfusion in experiment group compared with sham group,the return started from 48 h.The expression of TGF-β1 increased from 2 h to 24 h afterreperfusion in experiment group than sham group,the slowly return started from 48 h.The expression of BMP-7 was negatively related to TGF-β1.Conclusions The expression of BMP-7 will downregulate with the aggravated damage following ischemia-reperfusion injury,while the expression of TGF-β1 will upregulate with the aggravated damage following ischemia-reperfusion injury,They show negatively relationship in statistics.The BMP-7 and TGF-β1 are a pair of related factors in kidney following ischemia-reperfusion injury." @default.
- W2392728725 created "2016-06-24" @default.
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- W2392728725 date "2008-01-01" @default.
- W2392728725 modified "2023-09-25" @default.
- W2392728725 title "The Expression and Relationship of BMP-7 and TGF-β1 in Kidney Following Ischemia-Reperfusion Injury in Rat" @default.
- W2392728725 hasPublicationYear "2008" @default.
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