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- W2392738467 abstract "Objective To observe the changes of serum inflammatory cytokine,fibrinolytic and antifibrinolytic activities in patients with silent cerebral infarction(SCI). Methods The serum level of high-sensitivity C-reactive protein(hs-CRP) was measured by immunodiffusion turbidimetry in 53 patients with SCI and 55 cases of control group. The plasminogen activity(PLG : A),plasmin activity(PLM : A), tissue-type plasminogen activator (t-PA) activity, D-dimer (D-D), α_2-plasmin inhibitor(α_2-PI) activity and plasminogen activator inhibitor(PAI) activity were also measured in both groups. Results The level of hs-CRP was significantly higher in patients with SCI than in the control group[(15.36±4.30) mg/L vs (10.26±2.61) mg/L, P0.01]. The levels of PLM : A,t-PA and D-D were markedly lower in SCI group than in the control group [(35.84± 10.23)% vs (68.74±18.41)%,(0.11±0.01) U/ml vs (0.49±0.12) U/ml, and(0.36±0.14) mg/L vs (0.68±0.16) mg/L, P0.01, respectively],but PLG : A was not significantly different between the two groups (P0.05). The α_2-PI activity and PAI activity were significantly higher in SCI group than in the control group[(128.46±23.75)% vs (96.36±19.34)%,(0.86± 0.22) AU/ml vs (0.48±0.10) AU/ml, P0.01, respectively]. Conclusion Inflammatory processes and dysfunction of fibrinolytic and antifibrinolytic systems are involved in the pathogenesis of SCI." @default.
- W2392738467 created "2016-06-24" @default.
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- W2392738467 date "2009-01-01" @default.
- W2392738467 modified "2023-09-24" @default.
- W2392738467 title "Changes of serum inflammatory cytokine, fibrinolytic and antifibrinolytic activities in patients with SCI" @default.
- W2392738467 hasPublicationYear "2009" @default.
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