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- W2392738688 abstract "Objective:To observe the effects of treating fracture with different prescription of TCM in different healing stages,and to explore the optimal phasing method in treating fracture.Methods:A 2-mm-wide 1.5-mm-deep defect was bilaterally made as fracture healing model in the middle of the anterior part of the proximal one-third segment of tibia shaft of a SD rat.At first,6 SD rats were taken randomly from 222 male SD rats into the normal control group.Postoperatively,the others were divided randomly into four groups:the model control group,the one-period treatment group,the two-period treatment group and the three-period treatment group on average.The rats in one-period treatment group underwent TCM in 1 period,those in two-period treatment group in 2 periods,those in three-period treatment group in 3 periods,and those in both the model control group and the normal control group were given saline at the same dose.On day 1,3,5,7,9,12,15,21 and 28 after operation,6 rats in each group were selected randomly and sacrificed.Taking their right tibia as the object,the fracture healing was studied through observing and image analyzing of X-ray films and histology observation.Results:The X-ray observation showed that the score of the model control group were less than or equal to that of all treatment groups since the 7th day after operation.The average score of two-period treatment group was the highest.The image analysis result showed that all treatment groups had a higher callus filling rate (CFR) than that of model control group,and the fracture healing of all treatment groups were promoted for about 1 week.The average CFR of two-period treatment group was the highest.In histological examination,the result also showed that the histological scores of model control group were less than that of all treatment groups in the most time points after operation.From the 5th day to 15th day,the scores of two-period treatment group had the tendency of being higher than that of the one-period treatment and three-period treatment groups.The average score of two-period treatment group was higher than that of other three groups.But it had no significant difference.Conclusion:Using different prescription of TCM in different stages of fracture healing is necessary.And the two-period treatment may be the optimal way to treat bone fracture." @default.
- W2392738688 created "2016-06-24" @default.
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- W2392738688 date "2006-01-01" @default.
- W2392738688 modified "2023-09-22" @default.
- W2392738688 title "Radiological and histological study on treating fracture with different prescription of TCM in different healing stages" @default.
- W2392738688 hasPublicationYear "2006" @default.
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