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- W2392742455 abstract "Objective: To investigate the role of stat3 gene in the development of oral squamous cell carcinoma(OSCC).Method: The mRNA expression of Stat3 was tested by RT-PCR in 20 cases of OSCC. Stat3 exon for SH2 domain was sequenced in 7 cases of OSCC.Result: The mRNA expression of stat3 gene was different between carcinoma and nomal mucosa(P0.05). DNA sequencing results matched with Genbank stat3 sequence through NCBI-Blast was found no mutation in 5 cases,and 2 and 5 sites mutation respectively in another 2 cases.Conclusion: Stat3 gene may partly play signal transduction and transcriptional activation in the earlier period of OSCC development; Detecting the expression level of stat3 gene may contribute to predict lymph node metastasis and clinical stage of tumor. Mutation of stat3 exon for SH2 domain may associate with tumorgenesis of OSCC." @default.
- W2392742455 created "2016-06-24" @default.
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- W2392742455 date "2007-01-01" @default.
- W2392742455 modified "2023-09-26" @default.
- W2392742455 title "Study of the stats gene expression in oral squamous cell carcinoma and sequencing of the stat exon for SH2 domain" @default.
- W2392742455 hasPublicationYear "2007" @default.
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