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- W2392767354 abstract "Objective To observe the effect of erlotinib combined with radiotherapy on MKN45 cells so as to detect the mechanism of erlotinib in increasing the sensitivity of radiotherapy. Methods The effect of erlotinib and 5-fluorouracil(5-Fu)on MKN45 cells was determined by MTT method. Cell apoptosis rate and distribution at cell phase of MKN45 cells after treated with erlotinib, 5-Fu and radiation were assayed by flow cytometry. The expression of bcl-2 and bax protein of MKN45 cells treated with erlotinib,5-Fu and radiation was determined by Western Blot method. Results Erlotinib and 5-Fu could inhibit MKN45 cell growth and the inhibition enhanced significantly along with the increase of drug concentration and time(.P0.01). G2/M and G0/G1 phase cells increased significantly when the cells were treated with erlotinib and radiation combination, compared to that treated with 5-Fu combined with radiation group(70.32±0.65vs58.25±0.42,P0.01),Cell apoptosis also increased obviously compared to 5-Fu combined with radiation group(19.21±1.23vs13.11±0.76,P0.01). After treated with erlotinib and radiation,Bcl-2 protein expression decreased while Bax protein expression increased compared to the other group with significant difference(P0.01).Conclusions Erlotinib can increase MKN45 cell radiosensitivity by increasing G2/M and G0/G1 cell ratio, decreasing Bcl-2 protein expression and increasing Bax protein expression." @default.
- W2392767354 created "2016-06-24" @default.
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- W2392767354 date "2013-01-01" @default.
- W2392767354 modified "2023-09-28" @default.
- W2392767354 title "Obseruation of effect of erlotinib on radiosensitization mechanism of MKN45 cell lines" @default.
- W2392767354 hasPublicationYear "2013" @default.
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